Are Pain Medications Making Your Arthritis Worse?


By Renee Marie Walters

The pills you take to control joint pain may be making the problem worse—by increasing gastro-intestinal permeability, which is a major cause of arthritis and can occur in as little as one to seven days of taking pain medications.

My father suffers from arthritis, literally suffers from it! The joint pain and stiffness has him feeling nearly crippled on most days. I asked him what he is taking for it, and his response was “Well, not anything anymore. I was taking a prescription medication, but it seemed to quit working after about a month. And aspirin and pain medications scare me because they create openings in the intestines that not only cause the arthritis to worsen but also set the stage for various other diseases. I surely don’t need to make my arthritis worse or develop a more serious disease… simply for a few hours of pain relief.”

What do you take to control joint pain? Are you among most Americans who treat the painful symptoms with pain relievers or anti-inflammatory drugs – quick relief at the expense of worsening the condition? Or, are you working toward stopping the progression of your arthritis? There is a difference.

When joint pain flares up, most Americans reach for an aspirin, ibuprofen, acetaminophen or other pain reliever. We use pain relievers, called non-steroidal anti-inflammatory drugs (NSAIDs), because they work at reducing or eliminating pain. This temporary pain relief is not without strings attached though! Research shows these over-the-counter pain medications create gut permeability (Leaky Gut Syndrome) which is the leading cause of chronic disease and illness . . . arthritis, cancer, diabetes, heart disease, asthma, and allergies to name a few. Thus, the very medicine that you are taking to control your joint pain may be increasing your joint pain (as well as other diseases) for the rest of your life! Are you willing to relieve joint pain and stiffness temporarily at the expense of increasing the progression of arthritis and other more serious diseases?

There is hope, however. There is a way to protect ourselves when we take pain medication. Fortunately, medical research now shows that you can prevent the gastrointestinal injury that NSAIDs cause by taking colostrum (from dairy cows) at the same time. NSAIDs can increase gut permeability significantly, even if used for only a short time (1-7 days). A recent study (Playford, 1999) shows that colostrum keeps the GI tract from becoming more permeable, and can repair the damage already caused from taking NSAIDs. If you are going to reach for the pain relievers, make sure you also reach for the colostrum.

Nature’s Pharmacy
Researchers are now coming full circle to rediscover the most powerful natural substances to not only treat the symptoms of arthritis without negative side effects, but also to actually stop the progression of the disease. The healing benefits from the following natural components, when taken together, may actually help stop the progression of various forms of arthritis, along with helping to reduce the inflammation and pain.

Natural Product Solution #1: Colostrum – the foundation
Colostrum provides the foundation for stopping the progression of arthritis. Unlike any other substance, colostrum naturally contains IgF1 and other growth factors in a perfect combination to stimulate tissue regrowth and promote healing of the mucosal surfaces of the GI tract; therefore, healing the root of the problem.


Colostrum is the nutrient-rich, pre-milk liquid derived from a mother dairy cow within the first 48 hours after giving birth. It ensures a lifetime of good health for the newborn in two ways: it delivers antibodies and other immune factors to combat disease, and it delivers growth factors to protect the gastro-intestinal tract from becoming too permeable (a state of having large openings in the mucosal surfaces that will allow pathogens into the body). Since up to 90% of all disease enters the body through these openings in the GI tract, it is important to heal the damage that pain relievers, soft drinks, antibiotics, steroids and many other drugs or foods have caused.

Colostrum contains a myriad of components that specifically alleviate the symptoms of arthritis as well as stop the progression of the disease. Colostrum’s effectiveness lies in the synergistic combination of its powerful anti-inflammatory components, growth factors, immune factors, PRP, and sulfur micronutrients.

Anti-inflammatory components: Among others, colostrum contains cytokines and infopeptides. Cytokines are nature’s most powerful anti-inflammatory, and have been shown to mediate many vital biological processes, including inflammation (Feldmann 1999). Infopeptides are a protein derivative that reduce inflammation as well as allow the immune system to reorient and correct its response mechanism against autoimmune disease processes. Clinical observations of the effects of infopeptides in humans show reductions in inflammation, edema, pain and fever apparently regardless of cause (Nitsch 1998).

Growth factors: Colostrum is the only natural source of IgF-1, the growth factor known for its regenerative effects. The numerous growth factors in colostrum help prevent and repair damage to the gastrointestinal (GI) tract and connective tissue. By healing the intestinal barrier with colostrum’s growth factors, pathogens that cause disease, including various forms of arthritis, will not be allowed to enter the body. By healing the connective tissue, you may slow or stop the progression of the disease.

Immune factors: There is some evidence that like many other diseases, some forms of arthritis may be caused by pathogens entering the body through the intestinal tract. In the past decade, researchers have shown that intestinal bacteria are involved in the etiology of various forms of arthritis, including rheumatoid arthritis (Hazenburg 1992). Various studies show colostrum protects against common disease-promoting bacteria, such as E. coli, salmonella, shigella and yersinia. By providing antibodies to bacteria, viruses, toxins and yeasts, the various immune factors in colostrum prevent these pathogens from attaching to the intestinal mucosa and gaining access to the body.

PRP (proline-rich polypeptide): A compound, also known as colostrinin or transfer factor, shown recently to regulate and balance immune response. PRP relieves pain and swelling by stopping the progress of an overly aggressive immune response, such as over-production of T-cells and lymphocytes. It stops the overactive immune response that characterizes auto-immune diseases, like rheumatoid arthritis. And it has a wonderful side effect: clinical studies show that PRP reduces symptoms of Alzheimer’s disease by up to 50%.

Sulfur micronutrients: Colostrum contains bioavailable sulfur micronutrients such as MSM that have been shown to have a beneficial effect on the inflammation of arthritis.


In addition to the important combination of components that colostrum offers the body, it also stimulates the body to produce glutathione (GSH), the most important anti-oxidant for humans. Low intracellular glutathione has been implicated in or associated with hundreds of conditions relating to oxidative stress, including arthritis! Although chemical companies have made glutathione available in pill or powder form, researchers have determined that orally ingested glutathione has no effect on increasing glutathione levels. Colostrum, however, can stimulate the body to produce it naturally. It’s no wonder so many individuals have reported how their conditions either improve or disappear while taking colostrum.

Natural Product Solution #2: MSM
MSM, or methylsulfonylmethane, is a natural sulfur compound found in all living things. MSM is needed by the body for healthy connective tissues and joint function, along with the proper function of the immune system. MSM acts as an analgesic and anti-inflammatory. It also inhibits muscle spasm and increases blood flow.


According to a recent book by Lawrence, Jacob, and Zucker, entitled The Miracle of MSM, MSM can be a natural remedy for osteoarthritis, rheumatoid arthritis, fibromyalgia, tendonitis, bursitis, and muscular soreness. Dr. Lawrence has treated more than 1,000 patients with MSM. He says “The effects of MSM on rheumatoid arthritis almost mimic that of cortisone.” However, it does not have negative side effects as cortisone does. It has been shown to have no toxic build up in the body. In fact, according to Lawrence, “It’s safer than water.”

Natural Product Solution #3: Glucosamine sulfate
Glucosamine, also known as chitosamine, has been used for the alleviation of arthritis symptoms. Like MSM, it is a naturally occurring sulfur compound that has a beneficial effect on inflammation. Glucosamine attracts water into the cartilage matrix and stimulates the production of cartilage, which is important for maintaining healthy joints. There is evidence that glucosamine sulfate may provide pain relief, reduce tenderness, and improve mobility in patients with osteoarthritis, the most common form of arthritis (de Camara 1998). The sulfate form (glucosamine sulfate) is better absorbed by the body.

Natural Product Solution #4: Chondroitin sulfate
Chondroitin sulfate provides the structural components of joint cartilage, inhibits free radical enzymes that degrade joint cartilage and collagen, and facilitates the entry of glucosamine into inflamed joints. Many products offer a combination of glucosamine and chondroitin, as they effectively work together to improve joint function and provide pain relief. Like glucosamine, it has the ability to stimulate cartilage production as well as prevent enzymes from dissolving cartilage. Recent studies have shown very good results from long-term treatment with chondroitin sulfate in reducing pain and increasing range of motion.

Natural Product Solution #5: Cetyl myristoleate
Cetyl myristoleate, also known as CM or CMO, is a fatty acid complex for the nutritional support of degenerative joint conditions. It is important that CM is taken with a lipase enzyme to ensure that the stomach can properly digest it.

Harry W. Diehl, a researcher and chemist who worked for the National Institutes of Health for 40 years, discovered cetyl myristoleate. He received a U.S. patent on cetyl myristoleate for rheumatoid arthritis in 1977, and another for osteoarthritis in 1996. He discovered that it was the presence of cetyl myristoleate in mice that prevented them from developing joint problems (Diehl 1994). Dr. Diehl observed in scientific studies that animals given cetyl myristoleate in advance of being injected with an arthritis-producing solution were almost completely protected against the development of arthritis.


Cetyl myristoleate has shown significantly effective against osteoarthritis, as well as rheumatoid arthritis. It serves as a surfactant to lubricate joints, as well as an immune system modulator to regulate auto-immune problems. There are no confirmed reports of adverse side effects or interactions with medications or other natural substances. In order to increase absorption of CM into the body, it is best to avoid carbonated cola beverages, citrus juices, alcohol or caffeine while taking it.

What sets these natural alternative therapies for arthritis apart from over-the-counter and pharmaceutical drugs is they do not cause gastro-intestinal injury, which can set you up for future disease. Thus, if you start with a high quality colostrum product and add to it some or all of the other proven natural arthritis components, perhaps you may get your arthritis under control without sacrificing your future health.
Renee Marie Walters is a freelance health and fitness writer.


Case Studies

“I suffer with Rheumatoid Arthritis and Osteoporosis. The stiffness had become very bad and my activity was very limited. Since I began taking colostrum, I am seeing improvement; the stiffness has become less and I am walking and moving around with much more mobility. I am encouraged with the colostrum.”
HMM, Ohatchee, AL

“My story is very simple. I was diagnosed with arthritis in my knees and given a prescription for pain pills, but never took the first pill. I also had stiffness in my hands and sat each day working them by stretching them out and making a ball - back and forth. Then I was introduced to colostrum. The first day I took three capsules in the morning, and three that evening. I took the same the next morning and suddenly realized that afternoon that the stiffness and pain in my knees was gone. Also, my hands were no longer stiff and sore. I have been taking colostrum for approximately six months now, and have no signs of stiffness or soreness in my hands or knees. Recently I injured my knee while working – x-rays were taken and guess what? Right, no signs of arthritis! Thanks to the use of colostrum, it sure feels good to be free of the awful pain I endured for many years.”
Eileen T., Richmond, VA

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